QuEChERS extraction of benzodiazepines in biological matrices

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QuEChERS extraction of benzodiazepines in biological matrices

Two common analytical chemical problems often encountered when using chromatographic techniques in drug analysis are matrix interferences and ion suppression. Common sample preparation often involves the dilution of the sample prior to injection onto an instrument, especially for liquid chromatography-mass spectrometry (LC-MS) analyses. This practice frequently does not minimize or eliminate co...

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[Extraction techniques for analysis of venlafaxine and its metabolites in biological matrices].

Venlafaxine (VEN), which was introduced into therapy in 1990s is one of the most often used antidepressants. The monitoring of its concentration in the organism is recommended, particularly in the case when a patient suffers of others illnesses and is treated with different drugs, which can interfere with VEN. The most popular diagnostic material for the determination of VEN level is blood. The...

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Comparison of disposable pipette extraction and dispersive solid-phase extraction in the QuEChERS method for analysis of pesticides in strawberries.

In this study, we sought to assess the applicability of GC-MS/MS for the identification and quantification of 36 pesticides in strawberry from integrated pest management (IPM) and organic farming (OF). Citrate versions of QuEChERS (quick, easy, cheap, effective, rugged and safe) using dispersive solid-phase extraction (d-SPE) and disposable pipette extraction (DPX) for cleanup were compared for...

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Methadone Extraction by Modified QuEChERS and Liquid-Liquid Extraction from Post-Mortem Urine by GC-MS

QuEChERS stands for Quick, Easy, Cheap, Effective, Rugged, and Safe. This method is widely used to determine pesticides and was first introduced in 2003. Anastassiades and colleagues first introduced this method in 2003 to extract veterinary drugs from animal tissue [1]. Toxicology samples in forensic medicine are usually analyzed by Liquid-Liquid extraction (LLE) and solid phase extraction (SP...

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ژورنال

عنوان ژورنال: Journal of Pharmaceutical Analysis

سال: 2013

ISSN: 2095-1779

DOI: 10.1016/j.jpha.2013.04.004